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目的 研究人血管内皮因子的浓度与恶性肿瘤之间的关系。方法 用自制备的VEGF多克隆抗体对 342例肿瘤患者与正常人群血清VEGF浓度进行检测。结果 恶性肿瘤血清VEGF水平高于正常人 (P <0 .0 1) ,另外对 12 2例非小细胞肺癌患者血清VEGF水平进行了检测和动态观察 ,结果显示血清VEGF浓度大于 35 0 μg/l的患者两年生存率低于血清浓度小于 35 0 μg/l的患者 (P <0 .0 1)。 结论 VEGF是重要的肿瘤血管生成因子 ,其血清浓度的检测可作为评价肿瘤预后的一项有价值的指标 ,并为抗肿瘤血管治疗提供一定参考
Objective To study the relationship between the concentration of human vascular endothelial growth factor and malignant tumors. Methods Serum VEGF concentrations were measured in 342 cancer patients and normal controls using self-prepared VEGF polyclonal antibodies. Results Serum VEGF levels in malignant tumors were higher than those in normal subjects (P < 0.01). In addition, serum VEGF levels in 122 patients with non-small cell lung cancer were detected and observed dynamically. The results showed that the serum VEGF concentration was greater than 35 μg/l. The patient’s two-year survival rate was lower than those with a serum concentration of less than 350 μg/l (P 0.01). Conclusion VEGF is an important tumor angiogenesis factor. The detection of serum concentration can be used as a valuable index to evaluate the prognosis of tumors, and it provides a reference for anti-tumor vascular therapy.