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目的探讨不同病程的糖尿病肾病患者血脂变化的特点。方法将2型糖尿病(DM)患者分为糖尿病肾病组(DN)、非糖尿病肾病(NDN)组,根据尿白蛋白排泄率(UAER)及血肌酐(CRE)情况前者又分为三个亚组,分别采用比色法和免疫比浊法检测(DN)组与(NDN)的血甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血肌酐、糖化血红蛋白(HbA1C)和尿白蛋白排泄率(UAER)。结果 DN组血清TG水平为(2.48±2.04)mmol/L,NDN组为(1.68±1.09)mmol/L,两组相比差异有统计学意义(t=4.144,P<0.001);DN组血清TC水平为(5.73±1.67)mmol/L,高于NDN组(5.00±1.04)mmol/L,两组比较差异有统计学意义(t=4.249,P<0.001);DN组LDL-C为(4.06±2.04)mmol/L,NDN组(2.69±1.04)mmol/L,两组比较差异有统计学意义(t=4.249,P<0.001);DN组HDL-C明显低于NDN组(P<0.05或P<0.01)。结论 DN脂代谢紊乱程度明显高于NDN,且随病程迁延而加重。
Objective To investigate the changes of blood lipids in patients with diabetic nephropathy with different course of disease. Methods Patients with type 2 diabetes mellitus (DM) were divided into diabetic nephropathy group (DN) and non-diabetic nephropathy group (NDN). According to urinary albumin excretion rate (UAER) and serum creatinine (CRE), the former were divided into three subgroups (TG), cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), serum creatinine, hemoglobin A1c (HbA1C) and urinary albumin excretion rate (UAER). Results The serum triglyceride level in DN group was (2.48 ± 2.04) mmol / L and that in NDN group was (1.68 ± 1.09) mmol / L, there was significant difference between the two groups (t = 4.144, P <0.001) (5.73 ± 1.67) mmol / L, which was significantly higher than that of NDN group (5.00 ± 1.04) mmol / L, the difference was statistically significant (t = 4.249, P <0.001) 4.06 ± 2.04) mmol / L, and NDN group (2.69 ± 1.04 mmol / L). The HDL-C in DN group was significantly lower than that in NDN group (t = 4.249, 0.05 or P <0.01). Conclusions The degree of dyslipidemia of DN is obviously higher than that of NDN, and it aggravates with the course of disease.