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选择母亲HBsAg阴性新生儿,分10μg×3;20μg、10μg、10μg;30μg、10μg、10μg;三个免疫剂量组.按0、1、6程序接种.注射第一针后一年,检查抗-HBs,阳转率分别为87.69％,90.64％,88.79％,无统计学差异.10μg×3组免疫后1～4年抗-HBss/N值分别为83.47％、85.58％、84.22％,虽稍下降,但亦无统计学差异.三个免疫剂量组HBsAg阳转率极低,分别为0.71％、0.49％、0.74％.说明母亲HBsAg阴性新生儿注射乙肝疫苗10μg×3效果理想,剂量足够,不必盲目提高剂量.
The mother was immunized with HBsAg-negative newborns at doses of 10μg × 3, 20μg, 10μg, 10μg, 30μg, 10μg and 10μg.After immunization with 0, 1 and 6 doses, HBs and positive conversion rates were 87.69%, 90.64% and 88.79%, respectively, with no statistical difference.The anti-HBss / N values of 1μg to 4μg after 10μg × 3 group were 83.47%, 85.58% and 84.22% , But there was no statistical difference.The rate of HBsAg positive in the three immunized groups was very low, 0.71%, 0.49% and 0.74%, respectively, indicating that the mother HBsAg-negative newborns injected with 10μg × 3 hepatitis B vaccine had an ideal and sufficient dose, Do not blindly increase the dose.