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[目的]探讨抑酸剂、镇静剂、复方中药对大鼠应激性溃疡模型保护作用的机制。[方法]实验大鼠分为5组,各12只。中药组每天灌服复方中药心身1号2 ml,造模组及空白组灌等量0.85%氯化钠,共7 d;雷尼替丁组、阿普唑仑组于施加应激前0.5 h分别给予含各自成分的悬浊液2 ml。然后对给药4组水浸束缚,使之产生中医“气机失调”证和现代医学“应激性溃疡”的模型。比较5组胃黏膜的溃疡指数(UI)、病理及脑垂体中去甲肾上腺素(NE)、多巴胺(DA)、乙酰胆碱(Ach)的水平;检测造模组、中药组及空白组血清中免疫球蛋白A(IgA)、胃液中分泌型免疫球蛋白A(SIgA)的水平。[结果]造模组UI、NE及DA与空白组比较明显增高(P<0.01)、Ach明显降低。中药及雷尼替丁可明显降低UI及NE;雷尼替丁有明显降低DA的作用;阿普唑仑有升高Ach作用。造模组大鼠血清中IgA及胃液中SIgA的水平与空白组比较显著降低(P<0.01)。心身1号可显著提高造模组血清中IgA及胃液中SIgA的水平。[结论]各种药物通过不同的干预途径,保护胃黏膜、降低溃疡的形成。复方中药心身1号可明显改善应激导致的机体局部及全身免疫抑制状态。
[Objective] To explore the mechanism of antacids, sedatives and compound Chinese herbs in protecting rats from stress ulcer. [Methods] The experimental rats were divided into 5 groups, 12 rats each. The Chinese herbal medicine group was given 2 ml compound Chinese medicine Xinshen 1 daily, and the rats in the model group and the blank group were treated with 0.85% sodium chloride equivalent for 7 days. In the ranitidine group and the alprazolam group, Respectively given their respective components of the suspension 2 ml. Then the four groups of rats were drenched with water to make a model of traditional Chinese medicine “Qi Shu machine disorders” and modern medicine “stress ulcer”. The ulcer index (UI), pathology and norepinephrine (NE), dopamine (DA), and acetylcholine (Ach) levels in the pituitary gland of the five groups were compared. Globulin A (IgA), secreted immunoglobulin A (SIgA) in gastric juice. [Results] The UI, NE and DA in model group were significantly higher than those in blank group (P <0.01), Ach was significantly decreased. Chinese medicine and ranitidine can significantly reduce the UI and NE; ranitidine significantly reduced the role of DA; alprazolam increased Ach role. The levels of IgA in serum and SIgA in gastric juice in model group were significantly lower than those in blank group (P <0.01). Xin Shen 1 can significantly improve the model group serum IgA and gastric juice SIgA levels. [Conclusion] All kinds of drugs can protect the gastric mucosa and reduce the formation of ulcer through different ways of intervention. Compound Chinese medicine heart body 1 can significantly improve the stress caused by local and systemic immunosuppressive state.