胃内漂浮型控释制剂是一类具有密度小于1且能漂浮在胃液中的口服控释制剂。该制剂可延长胃肠道滞留时间,改善药物的吸收情况,有助于提高药物的生物利用度。本文介绍了胃内漂浮型控释制剂的性质,设计原理、剂型设计的关键因素赋形剂,以及剂型的体内、外鉴测方法。 Floating controlled release formulations in the stomach are a class of controlled release formulations that have a density of less than 1 and can float in the gastric fluid. The preparation can prolong the residence time of the gastrointestinal tract, improve the absorption of the medicine and help to improve the bioavailability of the medicine. This article describes the nature of the floating intragastric release of controlled release formulations, design principles, formulation of the key factors excipients, as well as formulations of in vivo and in vitro detection methods.