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本文研究的目的,一是确定哮喘病人应用泼尼松的药效是否有所不同,以及这种差异是否与病人对泼尼松的需要量有关;其次根据泼尼松所致嗜酸性白细胞减少的反应,以估价这一参数是否与该病的严重性有关,或与个体间对泼尼松的倾向性有关;第三是估价年龄上的差异在成年和儿童哮喘病人中泼尼松的倾向性。作者分析了10名类固醇依赖性哮喘儿童。其泼尼松需要量从隔日5mg到每日40mg。所有患者经皮试已确定为非变态反应性哮喘,肝肾功能均正常。试验周期为24小时。当这些患儿服用40mg泼尼松龙后,血浆浓度随时间推移而成双相性指数形式降低。泼尼松龙在体内的半衰期:受试儿童泼尼松龙的平均明显半衰期是2.5±0.5小时,小于健康人和哮喘成人所得结果(3.2±0.6小时)。平均血浆廓清率较正常人和哮喘成人为快,但二者均无统计学意义。在性
The purpose of this study is to determine whether the efficacy of prednisone in asthma patients is different and whether this difference is related to the patient’s need for prednisone. Second, according to prednisone-induced eosinophilia Response to assess whether this parameter is related to the severity of the disease or to the predisposition toward prednisone among individuals; and third is to assess the predisposition to predisposition to prednisone in adult and childhood asthma patients by age-differences . The authors analyzed 10 steroid-dependent asthmatic children. Its prednisone requirements from the next day 5mg to 40mg daily. All patients transdermal test has been identified as non-allergic asthma, liver and kidney function are normal. The test period is 24 hours. When these children take prednisolone 40 mg, the plasma concentration decreases bipolar index over time. The half-life of prednisolone in vivo: The predominant half-life of tested children with prednisolone was 2.5 ± 0.5 hours, less than that of healthy adults and adults with asthma (3.2 ± 0.6 hours). The mean plasma clearance rate was faster in both normal and asthmatic adults, but both were not statistically significant. In sex