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目的探讨血清骨保护素(OPG)水平、sRANKL水平与急性冠脉综合征(ACS)的关系。方法选取急性冠脉综合征患者50例,不稳定性心绞痛患者45例,32例冠脉造影正常无冠心病者为对照组。采用全自动生化仪测定LDL-C、hs-CRP等指标水平。采用ELISA法检测血清OPG、sRANKL水平,每例患者均行冠脉造影,并对冠脉进行Gensini评分。结果 ACS组患者血清OPG水平显著高于对照组及不稳定性心绞痛组(P<0.01),而血清sRANKL水平显著低于其他两组(P<0.01)。ACS组血清OPG水平与hs-CRP水平、Gensini评分成正相关(P<0.05),而sRANKL水平与hs-CRP水平、Gensini评分成负相关(P<0.01)。结论血清OPG水平升高、sRNAKL水平降低与ACS的冠状动脉病变严重程度密切相关,检测血清中两者的水平对ACS的辅助诊断、疗效观察及预后判断具有重要价值。
Objective To investigate the relationship between serum osteoprotegerin (OPG) level and sRANKL level and acute coronary syndrome (ACS). Methods Fifty patients with acute coronary syndrome, 45 patients with unstable angina pectoris and 32 patients with normal coronary artery disease without coronary angiography were selected as the control group. Using automatic biochemical analyzer LDL-C, hs-CRP and other indicators. Serum levels of OPG and sRANKL were detected by ELISA. Coronary angiography was performed in each patient and Gensini score was applied to the coronary arteries. Results Serum levels of OPG in ACS group were significantly higher than those in control group and unstable angina pectoris group (P <0.01), while serum sRANKL levels were significantly lower than those in the other two groups (P <0.01). Serum OPG level in ACS group was positively correlated with hs-CRP level and Gensini score (P <0.05), while sRANKL level was negatively correlated with hs-CRP level and Gensini score (P <0.01). Conclusions Serum OPG levels and sRNAKL levels are closely related to the severity of coronary artery lesion in ACS. Detecting the serum levels of both of them has important value in the diagnosis, curative effect and prognosis of ACS.