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本文用电泳免疫扩散法测定肝癌病人在疾病过程中,血清甲胎蛋白(AFP)含量的变化。文中选择临床确诊为原发性肝细胞癌的病人20例作为研究对象,其中经病理组织学证实为肝细胞型肝癌者有6例。全部病例经琼脂双扩散免疫学试验,血清AFP均为阳性。作者根据肝癌病人的病情及其在病程中所采用的治疗方法不同,而将全部病例分为四组,进行了血清AFP含量的测定与观察。从初步观察的结果可以看出,在治疗有效,病情好转时,血清AFP含量下降,甚至转为阴性(如肝癌手术切除后);而治疗无效,病情恶化时,则血清AFP含量升高。因此,血清AFP含量的变化有可能作为观察肝癌病人在疾病过程中,治疗效果、预后、病情恶化或复发的参考。
In this paper, electrophoretic immunodiffusion method was used to determine the changes of serum alpha-fetoprotein (AFP) levels in patients with liver cancer. In this article, 20 patients with clinically confirmed primary hepatocellular carcinoma were selected as subjects, and 6 of them were histologically confirmed as hepatocellular carcinoma. All cases were tested by agar double diffusion immunoassay and serum AFP was positive. According to the condition of liver cancer patients and the treatment methods adopted during the course of the disease, the authors divided all cases into four groups for the determination and observation of serum AFP levels. From the results of preliminary observations, it can be seen that when the treatment is effective and the condition is improved, the serum AFP content is reduced or even turned negative (such as after liver cancer surgery); when the treatment is ineffective and the disease is worsening, the serum AFP content is increased. Therefore, the change of serum AFP content may serve as a reference for the observation of liver cancer patients in the course of disease, treatment effect, prognosis, deterioration or recurrence of the disease.