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本文报告对30例血液病患者使用5氟胞嘧啶(5F-C)治疗深部霉菌病的经验,其中急淋2例,急粒12例,急单7例,急早幼粒3例,慢性白血病2例,恶性淋巴瘤4例。18例已并发霉菌感染,其中菌血症5例,肺炎8例,脑膜炎1例,腹膜炎1例,3例病灶不明但含漱液、尿、粪均检出同一霉菌,霉菌以白色念珠菌最多(11例)。其余12例为预防药。5FC 用量为100～200mg/kg/日,分3～4次内服,用药6～109天,中数27.7天。诊断霉菌感染的18例,用药6～59天,其中12例超过20天。
In this paper, we report the experience of 5F-C treatment of deep mycosis in 30 patients with hematological diseases, including 2 acute myeloma, 12 acute ones, 7 urgent ones, 3 acute promyelocytic, 3 chronic myelogenous leukemia 2 cases, 4 cases of malignant lymphoma. 18 cases had fungal infection, of which bacteremia in 5 cases, 8 cases of pneumonia, 1 case of meningitis, 1 case of peritonitis, 3 cases of lesions unknown but gargle, urine, feces were detected the same mold, fungus Candida albicans Most (11 cases). The remaining 12 cases were preventives. 5FC dosage of 100 ~ 200mg / kg / day, 3 to 4 times orally, medication 6 to 109 days, the median 27.7 days. 18 cases of mold infection diagnosis, medication 6 to 59 days, of which 12 cases more than 20 days.