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目的 探讨乳腺癌血清中纤维黏连蛋白 (FN )与Ⅳ型胶原 (Ⅳ -C)含量变化及其临床意义。方法 采用放射免疫法(RIA )测定 3 0例乳腺癌和 2 0例良性乳腺病变患者血清中FN、Ⅳ -C的含量。结果 乳腺癌患者血清中FN与Ⅳ -C含量明显高于良性乳腺病变组 (P <0 .0 5 )和健康对照组 (P <0 .0 5 ) ;而良性乳腺病变组与健康对照组比较则无显著性差异 (P >0 .0 5 ) ;术前血清FN、Ⅳ -C含量增高者其术后含量较术前含量明显降低 (P <0 .0 5 )。结论 血清FN与Ⅳ -C含量的检测在乳腺癌诊断、鉴别诊断以及疗效和预后判断等方面具有重要临床意义。
Objective To investigate the changes of fibronectin (FN) and type Ⅳ collagen (Ⅳ -C) in breast cancer and its clinical significance. Methods Radioimmunoassay (RIA) was used to determine the serum levels of FN and Ⅳ -C in 30 breast cancer patients and 20 benign breast lesions. Results The serum levels of FN and Ⅳ -C in breast cancer patients were significantly higher than those in benign breast lesions (P <0.05) and healthy controls (P <0.05), while those in benign breast lesions were significantly higher than those in healthy controls There was no significant difference (P> 0.05). Preoperative serum FN and IV-C levels were significantly lower than preoperative levels (P <0.05). Conclusion The detection of FN and Ⅳ -C in serum has important clinical significance in the diagnosis, differential diagnosis, curative effect and prognosis of breast cancer.