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观察了20例使用和19例未使用维生素E(VE)和维生素C(VC)的肺癌患者在介入化学疗法(支气管动脉内药物注射)前后血浆LPD(过氧化脂质,lipid peroxide)和红细胞SOD(超氧化物歧化酶;superoxide dismutase)水平的变化,结果:1)未使用VE、VC的肺癌患者在介入化学疗法后血浆LPO水平明显上升(P<0.02)、红细胞SOD水平显著下降(P<0.01);2)使用VE、VC的患者在介入化学疗法后血浆LPO明显下降(P<0.05),红细胞SOD水平上升,但差异无显著性(P>0.05);3)血浆LPO水平和VC摄入量之间有明显负相关,r=-0.55(P<0.01),而和VE间无明显负相关,r=-0.02(P>0.05)。
Plasma levels of LPD (lipid peroxidation) and erythrocyte SOD (SOD) in 20 patients with lung cancer who were treated with 19 and those without vitamin E (VE) and vitamin C (VC) before and after interventional chemotherapy (bronchial artery drug injection) (Superoxide dismutase) .Results: 1) The levels of plasma LPO in patients without VE and VC after chemotherapy were significantly increased (P <0.02), and the levels of SOD in erythrocytes were significantly decreased (P < 0.01). 2) In patients with VE and VC, plasma LPO was significantly decreased (P <0.05) and erythrocyte SOD level was increased after interventional chemotherapy, but the difference was not significant (P> 0.05); 3) Plasma LPO level and VC There was a significant negative correlation between the amount of input, r = -0.55 (P <0.01), but no significant negative correlation with VE, r = -0.02 (P> 0.05).