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介绍了组织微阵列的制作流程 ,重点描述了组织微阵列技术在以下三个方面的应用 :对已有的研究结果和统计学结论的重复 ;与基因微阵列联合使用 ,研究基因在不同条件下的差异表达 ,及差异表达基因在不同的组织标本中的表达情况 (包括拷贝数、组织学定位 ,基因编码蛋白为抗体的免疫组化研究等 ) ;与临床研究紧密结合 ,研究某些分子的变化与肿瘤治疗、预后间的关系。简要说明了组织微阵列技术存在问题和发展趋势
The fabrication flow of tissue microarray is introduced, and the application of tissue microarray technology is described in three aspects: the repetition of existing research results and statistical conclusions; and the use of gene microarray to study the effect of gene microarray on different conditions (Including copy number, histological localization, gene encoding protein as antibody immunohistochemistry, etc.); and clinical research in close association with the study of some of the molecular Changes and cancer treatment, the relationship between prognosis. The problems and trends of tissue microarray technology are briefly described