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对象与方法研究对象为1984～1994年收治的临床观察6个月以上,无瓣膜疾病,未施行预防性抗凝疗法的95例65岁以上阵发性房颤(E-PAF组)患者,男性54例,平均年龄76.6±5.5岁。并以79例(男59例,52.4±11.6岁)小于65岁阵发性房颤患者(Y-PAF组)和65岁以上老年性慢性房颤(ECAF)组95例(男55例,73.6±6.5岁)为对照组进行比较。合并高血压病者E-PAF(E-CAF)组占65％,Y-PAF组占43％。合并缺血性心血管病者E-PAF组占17％,Y-PAF组占11％。合并心肌病、二尖瓣脱垂综合征、窦机能不全综合征占0～5％,各组间无显著差异。合并甲亢者Y-PAF组占11％,比其他组显著增高。合并糖尿病、高脂血症者各组间无显著差异。缺血性脑血管病(iCVD)发病率的计算公式为“(观察期间发病次数)÷(总观察期间月数)×12×100”,求出每年发病率。iCVD分为血栓症和
Subjects and Methods The subjects were 95 patients with paroxysmal atrial fibrillation (E-PAF) over 65 years of age who had been treated for more than 6 months from 1984 to 1994 with no valvular disease and no prophylactic anticoagulant therapy, and men 54 cases, the average age of 76.6 ± 5.5 years. Ninety-nine patients (59 males, 52.4 ± 11.6 years old) younger than 65 years with paroxysmal atrial fibrillation (Y-PAF group) and 95 years old with chronic atrial fibrillation (ECAF) ± 6.5 years old) for the control group for comparison. E-PAF (E-CAF) group with 65% and H-PAF group with 43% with hypertension. E-PAF patients with ischemic cardiovascular disease accounted for 17%, Y-PAF accounted for 11%. Cardiomyopathy, mitral valve prolapse syndrome, sinus insufficiency syndrome accounted for 0 to 5%, no significant difference between the groups. Y-PAF combined with hyperthyroidism accounted for 11%, significantly higher than the other groups. Merger of diabetes, hyperlipidemia no significant difference between the various groups. The incidence of ischemic cerebrovascular disease (iCVD) was calculated as “(number of onset during observation period) ÷ (number of months during total observation period) × 12 × 100”, and the annual incidence was calculated. iCVD is divided into thrombosis and