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骨转移是恶性肿瘤常见并发症 ,实体癌至晚期有 2 0 %～70 %发生骨转移 [1 ]。癌性骨转移灶引起溶解性骨结构破坏而发生骨疼痛是最常见的症状 ,严重影响患者生活质量。双磷酸盐类药物治疗骨转移癌已有 10多年历史 ,骨磷 (氯甲双磷酸盐 )在国内已有使用报道 [2 ] 。体内外实验报?
Bone metastasis is a common complication of malignant tumors. Bone metastasis occurs in 20% to 70% of advanced solid tumors. [1] The most common symptoms of cancerous bone metastases are bone destruction caused by dissolved bone structure, which seriously affects the quality of life of patients. Bisphosphonates have been used for the treatment of bone metastases for more than 10 years. Bone-phosphate (chloromethyl bisphosphonate) has been reported in China [2]. In vitro and in vivo experiments reported?