自从1924年Graham 和Cole 发明口服胆囊造影以来,无论是造影剂还是检查技术都有了很大的改进。但是,仍然存在一些问题。其中,遇到最多的问题是第一次剂量检查时,胆囊不显影或显影不良。在一些正常人和大部分长期禁食油脂的病人,在摄入碘番酸后缺乏胆盐的肠肝循环可能是胆囊显影不良的重要原因。胆盐对碘番酸的肠内吸收和胆汁中的排泄都有明显的作用。 Ever since Graham and Cole invented oral cholecystography in 1924, there have been significant improvements in both contrast media and examination techniques. However, there are still some problems. Among them, the most encountered problem is the first dose examination, the gallbladder does not develop or develop poor. In some normal individuals and most patients with long-term fasting lipids, enterohepatic cycling lacking bile salts after ingestion of iophenate may be a significant cause of poor gallbladder development. Bile salts of iowan acid intestinal absorption and bile excretion have a significant role.