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目的:了解新疆维吾尔族人群人类白细胞抗原G(HLA-G)3'非翻译区(3'UTR)基因多态性.方法:提取100例维吾尔族基因组DNA,采用PCR方法扩增3'UTR,直接进行测序,分析基因多态性和单倍型分布情况.结果:100例维吾尔族人基因组DNA标本成功测序98人份,在HLA-G 3'UTR区检测到10个基因多态性,包括14bpDel/Ins、+3003C/T、+3010C/G、+3027A/C、+3035C/T、+3092T/G、3121T/C、+3142C/G、+3187MG、+3196C/G.这些基因位点之间强连锁,共有20个单倍型,其中单倍型2最多,占24.9％.结论:新疆维吾尔族HLA-G 3'UTR的基因多态性和基因连锁情况具有独特性,为进一步研究HLA-G在遗传、进化、免疫功能和相关疾病中的作用机制提供了研究依据.“,”Objective:To investigate gene polymorphsim of human leukocyte antigen G (HLA-G) 3'untranslated regions (3'-UTR)in Uygur,Xinjiang.Methods:Genomic DNA was extracted from 100 blood samples of Uygur population.Amplification of HLA-G 3'-UTR was performed by PCR.The productions were directly sequenced to analyze the frequency of genotypes and haplotypes.Results:There were 98 samples sequenced successfully.Ten single nucleic polymorphisms were found in HLA-G 3'UTR in Uygur populations consisting of 14bpDel/Ins,+3003C/T,+3010C/G,+3027A/C,+3035C/T,+3092T/G,3121T/C,+3142C/G,+3187A/G and +3196C/G.Strong linkage disequilibrium existed among these SNPs.It showed a higher HLA-G 3'-UTR haplotype diversity including 20 haplotypes and UTR-2 was the most one (24.9％).Conclusion:Polymorphisms and haplotypes of HLA-G 3'-UTR were distinct in Uygur populations.The data provide fundamental and critical information to explore mechanism of HLA-G in the role of genetics,evolution,immunity function and related diseases.