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目的检测稳定型心绞痛(SAP)患者和健康对照组血清细胞间黏附分子-1(ICAM-1)、血管细胞粘附分子-1(VCAM-1)水平的变化,观察ICAM-1、VCAM-1变化及对稳定型心绞痛患者患者的影响。方法采用ELISA法检测SAP患者及健康对照组血液ICAM-1、VCAM-1水平的变化,分析变化产生的可能机制。结果SAP组患者与对照组相比,血液ICAM-1、VCAM-1水平明显升高(P<0.05)。结论血液ICAM-1、VCAM-1水平变化对SAP血管炎症反应和病情稳定程度评价具有指导作用。
Objective To detect the changes of serum ICAM-1 and VCAM-1 in patients with stable angina pectoris (SAP) and healthy controls, and to observe the changes of ICAM-1, VCAM-1 Changes and effects on patients with stable angina pectoris. Methods The levels of ICAM-1 and VCAM-1 in blood were measured by ELISA in SAP patients and healthy controls, and the possible mechanism of the changes was analyzed. Results Compared with the control group, the levels of ICAM-1 and VCAM-1 in SAP group were significantly increased (P <0.05). Conclusion The changes of ICAM-1 and VCAM-1 levels in blood may play an important role in the evaluation of vascular inflammation and the degree of disease stability.