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以2,7-萘二酚为原料分别经六步反应合成了两个新的角型噻吩并萘并吡喃化合物6和8。两个目标化合物及所有新中间体的结构均经~1H NMR、MS、IR、元素分析充分表征。测定了化合物6的单晶分子结构,其特殊的分子平面刚性和α-吡喃与噻吩部分的活泼双键间的空间结构使之可能成为更有效的单官能团DNA嵌入剂。
Two novel pyrrole-thienopyranopyran compounds 6 and 8 were synthesized by 2-step reaction using 2,7-naphthalenediol as raw materials. The structures of the two target compounds and all the new intermediates were fully characterized by ~ 1H NMR, MS, IR and elemental analysis. The single crystal molecular structure of compound 6 was determined. The special molecular plane rigidity and the spatial structure between the active double bond of α-pyran and thiophene moiety make it possible to become a more effective monofunctional DNA intercalator.