多发性骨髓瘤是血液系统最常见的恶性肿瘤之一,而多发性骨髓瘤骨病会引起溶骨性病变及广泛的骨质疏松,其中椎体骨折是较严重的甚至危及生命的损害之一。超过半数的患者是因为出现了骨折、骨痛等症状来医院就诊,初诊时即已存在骨质破坏。化疗能有效抑制单克隆免疫球蛋白的恶性增生,但对于已经发生不可逆的骨质破坏却无能为力。 Multiple myeloma is one of the most common malignancies in the blood system, and multiple myeloma bone disease can cause osteolytic lesions and extensive osteoporosis, with vertebral fractures being one of the more serious or even life-threatening lesions . More than half of patients because of the emergence of fractures, bone pain and other symptoms to the hospital for treatment, there is a new bone destruction. Chemotherapy can effectively inhibit the malignant proliferation of monoclonal immunoglobulin, but for irreversible bone destruction has been powerless.