患者用抗生素时的不配合情况极为普遍,这可能是临床疗效差的主要因素之一。既往对幽门弯曲菌(CP)性胃炎患者的研究表明,羟氨苄青霉素对 CP 有良好的近期清除效果,但大部份患者治疗后可迅速复发。为客观了解这些患者对治疗的配合情况,作者检测了治疗期间尿中的羟氨苄青霉素的浓度。病人和方法共23例因胃肠道症状而作内镜检查的患者,经组织学及细菌学检测证实为 CP 性胃炎。将患者随机分为用羟氨苄青霉素1.5g,每12h 一次,共8天,或用上述方案后再用1.0g 羟氨苄青霉素作28天的维持治疗。后在第8天、4周及6个月时复查内镜.在治疗后7天及21～28天时用标准的琼脂扩散生 Patients with antibiotics when the unmatched situation is extremely common, which may be one of the main factors of poor clinical efficacy. Previous studies of patients with Pylose-type gastritis showed that amoxicillin had a good recent clearance of CP, but most patients relapsed rapidly after treatment. To objectively understand how well these patients are treated with treatment, the authors examined the concentration of amoxicillin in the urine during treatment. Patients and Methods A total of 23 patients with endoscopy due to gastrointestinal symptoms were confirmed by histology and bacteriological examination as CP gastritis. Patients were randomized to 1.5 g of amoxicillin, once every 12 h, for a total of 8 days, or with the above regimen followed by 1.0 g of amoxicillin for 28 days of maintenance treatment. Endoscopy was reviewed at day 8, 4, and 6 months with standard agar diffusion at 7 days and 21-28 days after treatment