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据报道在系统性红斑狼疮(SLE)病人中,心血管疾病,如心肌梗塞和脑栓塞的发生率升高,动脉粥样硬化的形成也加快。血栓形成与抗心磷脂抗体(aCL)有关,但该抗体与动脉粥样硬化的关系尚不清楚。除了推测SLE动脉粥样硬化的出现是长期类固醇治疗的结果外,还没有关于动脉粥样硬化加快的解释。本研究目的是探明未服用类固醇的SLE病人中血清高密度脂蛋白(HDL),载脂蛋白A1(ApoA1),总胆固醇低下是否与aCL有关。
It has been reported that in patients with systemic lupus erythematosus (SLE), the incidence of cardiovascular diseases such as myocardial infarction and cerebral embolism increases, and the formation of atherosclerosis also accelerates. Thrombosis and anticardiolipin antibodies (aCL), but the relationship between the antibody and atherosclerosis is unclear. In addition to speculating that the appearance of SLE atherosclerosis is the result of long-term steroid therapy, there is no explanation for the acceleration of atherosclerosis. The aim of this study was to determine if serum HDL, ApoA1, and total cholesterol were associated with aCL in steroid-naive SLE patients.