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黑热病(内脏利什曼病)对印度次大陆的威胁已有一个多世纪了。自从1977年以来,国家的疟疾控制计划之一——杀虫剂滞留喷洒杀灭昆虫的措施停止后,恒河北部地区比哈尔州受到黑热病更严重的侵袭。最近,该病不仅在这个州流行,而且向邻近的孟加拉湾西部各州以及孟加拉国和尼泊尔传播。近年来,还发现了对黑热病的首选治疗药物五价锑,产生抗药性的病例明显增多。本文报告一个对葡萄糖酸锑钠产生高度耐药性特殊病例,杜氏利什曼原虫出现在脑脊液中。
The kala-azar (visceral leishmaniasis) threat to the Indian subcontinent has been more than a century. Since 1977, one of the country’s malaria control programs, the insecticide detention and spraying to kill insects stopped, and the state of Bihar in the northern Ganges was severely hit by kala-azar. Recently, the disease has spread not only in this state, but also in neighboring western states of Bangladesh, Bangladesh and Nepal. In recent years, it has also found that pentavalent antimony, the drug of choice for the treatment of kala-azar, has been found to have significantly increased resistance. This article reports a special case of highly resistant antimony sodium gluconate, Leishmania donovani appears in cerebrospinal fluid.