论文部分内容阅读
目的 :研究血清透明质酸 (HA)、层粘连蛋白 (LN)及IV型胶原 (IV -C)水平与肝纤维化及肝癌转移的关系。方法 :应用放射免疫法测定 6 5例慢性病毒性肝炎、10 8例肝炎后肝硬化及 5 1例原发性肝癌患者血清HA、LN及IV -C水平。结果 :肝癌、肝硬化及慢性肝炎患者的血清三项指标均明显高于对照者 ,肝硬化患者的上述指标还明显高于慢性肝炎者 ,其敏感性 (84.9% )及准确性 (79.8% )以HA最高 ,而特异性 (96 .9% )则以三项指标联检最佳。此外 ,伴肝外转移的血清LN及IV -C含量还显著高于无肝外转移者。结论 :血清三项指标基本与慢性肝炎及肝硬化的发展过程相一致 ,可作为反映肝纤维化程度及监测肝癌浸润转移的临床指标。
Objective: To study the relationship between the levels of serum hyaluronic acid (HA), laminin (LN) and type IV collagen (IV-C) in liver fibrosis and liver cancer metastasis. Methods: Serum levels of HA, LN and IV-C in 65 patients with chronic viral hepatitis, 108 with posthepatitic cirrhosis and 51 with primary liver cancer were measured by radioimmunoassay. Results: The three indexes of serum in patients with liver cancer, liver cirrhosis and chronic hepatitis were significantly higher than those in controls, and the above indexes in patients with cirrhosis were significantly higher than those in patients with chronic hepatitis (84.9%) and accuracy (79.8%) The highest HA, while the specificity (96.9%) is the best combination of three indicators. In addition, the serum levels of LN and IV-C with extrahepatic metastasis were significantly higher than those without extrahepatic metastasis. Conclusion: The three indexes of serum are basically consistent with the development of chronic hepatitis and cirrhosis, which can be used as a clinical index reflecting the degree of liver fibrosis and monitoring the invasion and metastasis of hepatocellular carcinoma.