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在休克的发病原理中,某些体液因子占有重要的地位。1943年曾有人报告压迫胸导管可使实验动物出现休克,并指出有毒性物质存在。1964年Tice和Dumont在内脏血管闭塞所致休克的动物淋巴中发现有毒性物质,但亦未能阐明其本质。最近Glenn和Lefer观察到当血容量减少后休克猫胸导管中的淋巴液对心脏有毒性作用。主要是引起溶酶体蛋白水解酶和心肌抑制因子(Myocardial depressant factor-MDF)的释放。这些发现阐明了早期所发现的休克毒性因子。
In the pathogenesis of shock, some of the body fluid factor occupies an important position. It was reported in 1943 that compression of the thoracic duct could cause shock in experimental animals and pointed to the presence of toxic substances. In 1964, Tice and Dumont found toxic substances in the lymphatic vessels of animals that were shock-induced by visceral vascular occlusion, but failed to elucidate their nature. Recently Glenn and Lefer observed that the lymph in the thoracic duct of the cat when shock volume is reduced is toxic to the heart. Mainly caused by the release of lysosomal proteases and Myocardial depressant factor (MDF). These findings shed light on the shock toxicities found earlier.