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目的观察善得定联合白蛋白治疗对肝肾综合征的治疗效果。方法将29例HRS患者分两组,对照组应用小剂量多巴胺及利尿剂治疗;治疗组应用善得定(Octreotid)联合白蛋白治疗。观察两组患者治疗前后24h尿量、肾功能、肾素、醛固酮水平变化。结果治疗组应用善得定联合白蛋白治疗后,HRS患者尿量增加,肾功能改善,BUN、SCr较治疗前显著下降(P<0.01),同时检测肾素、醛固酮水平随肾功能的恢复而降低(P<0.01)。结论善得定联合白蛋白治疗,有助于HRS患者肾内血流动力学的重新平衡,促进HRS肾功能的可逆性恢复,是治疗肝硬化腹水并发HRS的较为有效的方法。
Objective To observe the effect of combination of albumin and dextrine in the treatment of hepatorenal syndrome. Methods 29 cases of HRS patients were divided into two groups. The control group was treated with low dose of dopamine and diuretic. The treatment group was treated with Octreotid combined with albumin. Urine volume, renal function, renin and aldosterone levels were observed before and after treatment in two groups. Results After treatment with SHD and albumin, the urine volume and renal function of HRS patients were significantly improved. The levels of BUN and SCr were significantly decreased (P <0.01), and the levels of renin and aldosteronism were detected with the recovery of renal function Decreased (P <0.01). Conclusions Gooddetermining combined with albumin treatment is helpful to rebalance intrarenal hemodynamics in HRS patients and promote the reversible recovery of renal function of HRS. It is a more effective method for the treatment of patients with cirrhosis and ascites complicated by HRS.