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目的:探讨低分子肝素对早发型重度子痫前期治疗情况,并分析治疗对母婴结局的影响。方法:选择我院2012年1月~12月收治的早发型重度子痫前期患者120例,随机分为观察组和对照组,每组60例。对照组给予常规治疗,观察组在对照组治疗基础上加用低分子肝素。比较两组血压、24 h尿量、尿蛋白定量、尿酸、血常规、凝血功能及孕周延长时间、围产儿结局和产妇并发症。结果:两组患者临床指标无差异(P>0.05),治疗后两组血压、24 h尿量、尿蛋白定量均显著改善,观察组红细胞压积、纤维蛋白原降低明显高于对照组,而观察组患者的产妇并发症和围产儿不良结局发生率均低于对照组,且产妇孕周延长时间明显多于对照组,差异有统计学意义(P<0.05)。两组患者的血小板、凝血酶原时间等治疗前后均无明显变化(P>0.05)。结论:低分子肝素对早发型重度子痫前期的治疗能有效抑制高凝状态,改善肾功能,延长孕周时间,可有效减少患者并发症的发生,改善母婴预后,值得临床推广应用。
Objective: To investigate the treatment of premature eclampsia with low molecular weight heparin and analyze the effect of treatment on the outcomes of maternal and infant. Methods: A total of 120 early-onset severe preeclampsia patients admitted from January 2012 to December 2012 in our hospital were randomly divided into observation group and control group, with 60 cases in each group. Control group given conventional treatment, the observation group in the control group based on the addition of low molecular weight heparin. Blood pressure, 24 h urinary volume, urinary protein, uric acid, blood routine, coagulation, gestational age, perinatal outcome and maternal complications were compared between the two groups. Results: There was no difference in clinical indexes between the two groups (P> 0.05). After treatment, the blood pressure, 24 h urinary volume and urinary protein in both groups were significantly improved. The hematocrit and fibrinogen in the observation group were significantly lower than those in the control group The incidences of maternal complications and perinatal adverse outcomes in the observation group were lower than those in the control group, and the prolonged gestational weeks were significantly longer in the observation group than in the control group (P <0.05). There were no significant changes in platelet and prothrombin time before and after treatment in both groups (P> 0.05). Conclusion: The treatment of premature eclampsia with low molecular weight heparin can effectively inhibit hypercoagulable state, improve renal function and prolong the gestational age. It can effectively reduce the incidence of complications and improve the prognosis of maternal and infant. It is worthy of clinical application.