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目的了解深圳市福田区慢性病防治院2008-2012年103株淋球菌对五种抗菌药的耐药性及产青霉素酶淋球菌PPNG和高水平耐四环素淋球菌TRNG的流行趋势。方法用琼脂稀释法测定头孢曲松、大观霉素、环丙沙星、四环素及阿奇霉素的最低抑菌浓度(MIC),用头孢硝噻吩纸片检测β-内酰胺酶。结果 103株淋球菌检出PPNG35株(34.0%),TRNG62株(60.2%),环丙沙星耐药率达96.1%,高度耐药株(MIC≥16 mg/L)51株(49.5%),阿奇霉素耐药率为16.5%,头孢曲松、大观霉素未发现耐药菌株、抗菌活性均很强。结论持续性监测淋球菌的耐药性变迁是临床减少淋球菌耐药菌珠出现的有效办法。
Objective To investigate the epidemic trend of 103 strains of Neisseria gonorrhoeae against five kinds of antibacterials and the trend of producing penicillinase-producing Neisseria gonorrhoeae PPNG and high-level tetracycline-resistant Neisseria gonorrhoeae TRNG from 2008 to 2012 in Futian District, Shenzhen. Methods The minimum inhibitory concentration (MIC) of ceftriaxone, spectinomycin, ciprofloxacin, tetracycline and azithromycin was determined by agar dilution method, and β-lactamase was detected by cefotaxel paper. Results 103 strains of Neisseria gonorrhoeae detected PPNG35 (34.0%), TRNG62 (60.2%), ciprofloxacin 96.1% and highly resistant strains (MIC≥16 mg / L) 51 (49.5% , Azithromycin resistance rate was 16.5%, ceftriaxone, spectinomycin drug-resistant strains were not found, the antibacterial activity are strong. Conclusion The continuous monitoring of drug resistance of Neisseria gonorrhoeae is a clinically effective method to reduce the emergence of drug-resistant bacterial strains of Neisseria gonorrhoeae.