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70只大鼠和20只豚鼠各随机分成两组,观察出血热预防片对动物免疫功能及血浆环核苷酸的影响。结果表明:该预防片能提高大鼠 T 淋巴细胞转化率,促进总 E 玫瑰花环的形成,抑制豚鼠Ⅰ型变态反应程度,升高大鼠血浆中 cAM P的水平和 cAMP/cGMP值(对 cGMP 影响不显),与对照组相比差异均有统计学意义提示增强 T 细胞免疫功能、抑制Ⅰ型变态反应,以及通过调节环核苷酸系统来发挥一系列效应,可能是其预防出血热的重要机理。
The 70 rats and 20 guinea pigs were randomly divided into two groups to observe the effects of hemorrhagic fever preventive tablets on immune function and plasma cyclic nucleotides. The results showed that the preventive tablets can increase the conversion rate of T lymphocytes in rats, promote the formation of total E rosettes, inhibit the degree of type I allergy in guinea pigs, and increase the level of cAMP and cAMP/cGMP values in rat plasma (effects on cGMP Insignificantly, the statistically significant difference between the control group and the control group suggests that enhancing T cell immune function, inhibiting type I allergies, and exerting a series of effects by regulating the cyclic nucleotide system may be important in preventing hemorrhagic fever. mechanism.