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科技日报上海7月18日电通过4年攻关,第二军医大学基础部细胞生物学教研室主任胡以平教授课题组,实现了小鼠成纤维细胞向肝干细胞分化的重编程,并证明了这一方法所产生的肝干细胞,与活体内自然存在的肝干细胞具有相似的生物学特性。今天,国际权威学术刊物《细胞·干细胞》在线发表了相关研究成果。该课题组于兵博士和何志颖副教授为论文的共同第一作者。肝干细胞是肝脏中数量极少、但可分化产生肝细胞和胆管上皮细胞的“种子细胞”。这两种细胞可以参与肝脏细胞的自然更新和肝脏组织的损伤修复,对肝脏的正常结构和功能的维持具有重要作用。上世纪90年代初期,胡以平在乙肝转基因小鼠的研究中意识到肝干细胞的存在并开始研究。随
Shanghai Science and Technology Daily Shanghai July 18 through 4 years of research, the Second Military Medical University Department of Cell Biology, director of the Division of Biology and Biology Professor Hu Yiping group to achieve mouse fibroblasts to liver stem cell differentiation reprogramming and proved this method The resulting liver stem cells have similar biological characteristics to the naturally occurring liver stem cells in the living body. Today, the international authoritative academic journal “Cell Stem Cells” published relevant research results online. The group in Dr. Bing and Associate Professor Ho Chi-ying as co-authors. Liver stem cells are very few in the liver but differentiate into “seed cells” that produce hepatocytes and biliary epithelial cells. These two kinds of cells can participate in the natural regeneration of liver cells and liver tissue damage repair, the normal structure and function of the liver to maintain an important role. In the early 90s of last century, Hu Yiping in the study of hepatitis B transgenic mice aware of the existence of liver stem cells and began to study. With