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[目的]观察益气活血通络汤联合化疗对中晚期非小细胞肺癌生存质量的影响。[方法]使用随机平行对照方法,将61例住院患者随机分为两组,对照组30例根据患者的病理类型及机体状况制定化疗方案,并予以支持治疗。治疗组31例化疗方案同对照组。化疗期间及间歇期使用益气活血通络汤(黄芪30g,太子参、茯苓、白术各15g,薏苡仁30g,当归、丹参各15g,川贝母9g,法半夏、桔梗各12g,杏仁9g,甘草5g)1剂/d,早晚分服。28d为1个周期,连续治疗2个周期为1个疗程(化疗期间及间歇期对症治疗化疗不良反应)。观测KPS评分、体重变化、临床症状、病灶变化、毒副反应。治疗1疗程,判定疗效。[结果]KPS评分,治疗组显著增加(P<0.01),对照组变化不明显(P>0.05),治疗组优于对照组(P<0.01);治疗组体重增加(P<0.01),对照组体重减少(P>0.05),治疗组体重改善优于对照组(P<0.01);临床症状均有不同程度缓解,咳嗽、气急、乏力治疗组缓解优于对照组(P<0.05):痰血、发热、食欲不振组间差异不明显(P>0.05);病灶变化有效率及稳定率两组无明显差异(P>0.05);两组均出现不同程度白细胞、血红蛋白、血小板减少,转氨酶、胆红素、肌酐升高及恶心呕吐,其中白细胞减少、恶心呕吐发生治疗组明显低于对照组(P<0.05)。[结论]益气活血通络汤联合化疗可稳定瘤体,改善临床症状及体能状态、增加体重,减少化疗不良反应发生,提高患者生存质量。
[Objective] To observe the effect of Yiqi Huoxue Tongluo Decoction combined with chemotherapy on the quality of life of advanced non-small cell lung cancer. [Methods] Using randomized parallel control method, 61 inpatients were randomly divided into two groups, the control group of 30 patients according to the pathological type and body condition to develop chemotherapy and supportive treatment. The treatment group 31 cases of chemotherapy with the control group. During chemotherapy and intermittent use of Yiqi Huoxue Tongluo Decoction (Astragalus 30g, heterophylla, Poria, Atractylodes 15g, Coix Seed 30g, Angelica, Salvia 15g, Fritillaria 9g, France Pinellia, Campanulaceae 12g, almond 9g , Licorice 5g) 1 / d, morning and evening service. 28d for a cycle, continuous treatment of 2 cycles for a course of treatment (during chemotherapy and intermittent symptomatic treatment chemotherapy adverse reactions). Observed KPS score, weight changes, clinical symptoms, lesions, toxic and side effects. Treatment of a course of treatment to determine the efficacy. [Results] The KPS score increased significantly in the treatment group (P <0.01) and in the control group (P> 0.05), but was significantly higher in the treatment group than in the control group (P <0.01) The weight of the treatment group was better than that of the control group (P <0.01). The clinical symptoms were relieved in varying degrees. The relief of cough, shortness of breath and fatigue group was better than that of the control group (P <0.05) There was no significant difference between the two groups (P> 0.05). The levels of white blood cells, hemoglobin, thrombocytopenia, transaminase, Bilirubin, creatinine increased and nausea and vomiting, including leukopenia, nausea and vomiting occurred in the treatment group was significantly lower than the control group (P <0.05). [Conclusion] Yiqi Huoxue Tongluo Decoction combined with chemotherapy can stabilize the tumor, improve clinical symptoms and physical fitness, increase body weight, reduce adverse reactions of chemotherapy and improve patients’ quality of life.