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目的:探讨中西医结合治疗慢性肾炎疗效及配合护理干预对患者肾功能的影响。方法:将120例慢性肾炎患者根据随机分组法分为观察组和对照组各60例。对照组采用阿魏酸哌嗪片口服治疗,观察组在对照组治疗方案的基础上结合黄葵胶囊治疗。2组患者均于入院后给予护理干预,2组疗程均为8周。比较分析2组临床疗效、24 h尿蛋白定量和血浆白蛋白水平、肾功能水平及不良反应。结果:总有效率观察组96.67%,高于对照组86.67%,差异有统计学意义(P<0.05);2组24 h尿蛋白定量治疗后比治疗前减少,差异有统计学意义(P<0.05),而血浆白蛋白治疗后较治疗前增加,差异有统计学意义(P<0.05);观察组24h尿蛋白定量治疗后低于对照组,差异有统计学意义(P<0.05),而血浆白蛋白治疗后高于对照组,差异有统计学意义(P<0.05);2组尿素氮(BUN)和血肌酐(Cr)治疗后均较治疗前减少,差异有统计学意义(P<0.05);观察组BUN和Cr治疗后低于对照组,差异有统计学意义(P<0.05);治疗期间2组均未见明显不良反应。结论:中西医结合治疗同时配合护理干预慢性肾炎患者疗效显著,可改善患者肾功能,且无明显不良反应,临床应用安全可靠,具有重要研究价值。
Objective: To explore the effect of combining traditional Chinese and western medicine on chronic nephritis and the effects of nursing intervention on renal function in patients. Methods: 120 patients with chronic nephritis were randomly divided into observation group and control group, 60 cases in each group. The control group was treated with piperazine ferulate tablets orally, and the observation group was treated with Huangkui capsule on the basis of the control group. Two groups of patients were given nursing intervention after admission, two groups of treatment were 8 weeks. The clinical curative effect, 24-hour urine protein and plasma albumin level, renal function and adverse reactions were compared and analyzed. Results: The total effective rate in the observation group was 96.67%, which was higher than that in the control group (86.67%, P <0.05). The 24 h urinary protein in the two groups decreased after the quantitative treatment compared with that before treatment, the difference was statistically significant (P < 0.05), while plasma albumin increased after treatment compared with that before treatment (P <0.05). The 24-hour urinary protein in the observation group was lower than that in the control group after the quantitative treatment (P <0.05), while the difference was statistically significant Plasma albumin after treatment was higher than the control group, the difference was statistically significant (P <0.05); two groups of urea nitrogen (BUN) and serum creatinine (Cr) decreased after treatment compared with before treatment, the difference was statistically significant (P < 0.05). The BUN and Cr levels in the observation group were lower than those in the control group (P <0.05). No significant adverse reactions were observed in the two groups during the treatment. Conclusion: Integrative Chinese and Western medicine combined with nursing intervention in patients with chronic nephritis significant effect, can improve renal function in patients without obvious adverse reactions, clinical application of safe and reliable, has important research value.