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目的:比较三康胶囊(SKC)与几种常用抗缺氧中药及中成药对缺氧小鼠的保护作用,为其应用于降低高原反应的发生率、提高高原部队的作战能力提供实验依据。方法:建立小鼠常压密闭缺氧和急性减压缺氧模型,并模拟高原海拔缺氧环境,灌胃给予高、低剂量的三康胶囊(1.5、0.5 g/kg),考察三康胶囊和几种中(成)药(复方党参片、心脑欣胶囊、红景天胶囊及红景天生药等)对缺氧小鼠存活时间与死亡率的影响。结果:与几种中(成)药比较,三康胶囊能显著延长小鼠常压密闭缺氧存活时间和急性减压缺氧存活时间;并能降低模拟高原海拔环境下动物的死亡率。结论:三康胶囊具有显著的抗缺氧作用,合理配伍的中药复方在抗缺氧方面具有单味中药或中药提取部位无法比拟的优势。
Objective: To compare the protective effect of Sankang Capsule (SKC) and several commonly used anti-hypoxic herbs and proprietary Chinese medicines on hypoxic mice and provide experimental evidence for its application in reducing the incidence of altitude sickness and enhancing the combat capability of plateau troops. Methods: The model of hypoxia and acute hypobaric hypoxia was established in mice under normal pressure and hypoxia environment was simulated at high altitude. The high and low doses of Sankang capsule (1.5, 0.5 g / kg) And several (into) drugs (compound Codonopsis, Xinnao Xin capsules, Rhodiola capsules and rhodiola crude drugs, etc.) on hypoxic mice survival time and mortality. Results: Compared with several Chinese medicines, Sankang Capsule could significantly prolong the time of hypobaric hypoxia and acute hypobaric hypoxia survival in mice under normal pressure and reduce the mortality of animals simulated in altitude environment. Conclusion: Sankang capsule has significant anti-anoxia effect. The traditional Chinese medicine compound with reasonable compatibility has unparalleled advantages in anti-hypoxia for single Chinese medicine or traditional Chinese medicine extraction parts.