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目的 :总结综合治疗晚期前列腺癌的疗效。方法 :回顾性分析我院 1998年 1月～ 2 0 0 3年 6月收治的 45例晚期前列腺癌患者 ,C期 10例 ,D期 3 5例 ,腺癌 42例 ,鳞癌 1例 ,未分化癌 2例 ,采用双侧睾丸切除术、睾丸切除加内分泌治疗或内放射治疗。结果 :45例患者治疗后下尿路梗阻症状、转移性骨痛均得到明显改善 ,血清PSA在治疗后三个月内均显著下降 ,其中 15例降至正常范围。 10例PSA下降后出现反弹。结论 :以内分泌治疗为主的综合治疗是晚期前列腺癌的主要治疗方法 ,可以提高生活质量 ,延长生存时间 ,定期PSA复查可以及早发现肿瘤复发。
Objective: To summarize the curative effect of comprehensive treatment of advanced prostate cancer. Methods: A retrospective analysis of 45 cases of advanced prostate cancer admitted to our hospital from January 1998 to June 2003, including 10 cases of stage C, 35 cases of stage D, 42 cases of adenocarcinoma, 1 case of squamous cell carcinoma, Differentiated carcinoma in 2 cases, bilateral orchiectomy, orchiectomy plus endocrine therapy or internal radiation therapy. Results: After treatment, the symptoms of lower urinary tract obstruction and metastatic bone pain were all improved in 45 patients. The serum PSA decreased significantly within three months after treatment, of which 15 patients fell to the normal range. 10 cases of PSA rebounded after the decline. Conclusion: The comprehensive treatment with endocrine therapy is the main treatment for advanced prostate cancer, which can improve the quality of life and prolong the survival time. Periodic PSA review can detect tumor recurrence early.