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目的：探讨酸碱双点电位法在有机弱酸弱碱性药物分析中的应用，并选择适宜的实验条件。方法：在１ ｍ ｏｌ／ Ｌ Ｋ Ｃｌ溶液中，分两次加入 Ｖ１ 和 Ｖ２ 体积 Ｈ Ｃｌ标准溶液，测定西咪替丁的含量，并与药典法对照。结果：在适宜的实验条件范围内，用酸碱双点电位法与药典法测定西咪替丁的含量结果相符合。结论：酸碱双点电位法具有简便、快速、准确等特点，在有机弱酸弱碱性药物分析中有一定的实用前景。
Objective: To explore the application of acid-base two-point potential method in the analysis of weakly acidic and weakly basic organic drugs, and select the appropriate experimental conditions. Methods: In 1 mol / L KCl solution, V1 and V2 volumes of H Cl standard solution were added in two batches. The content of cimetidine was determined and compared with the pharmacopoeia. Results: In the range of suitable experimental conditions, the acid-base two-point potential method was consistent with the results of pharmacopoeia in the determination of cimetidine. Conclusion: The double-point potentiometric method is simple, rapid and accurate. It has some practical perspectives in the analysis of weakly acidic and weakly basic organic drugs.