抗原刺激机体后所产生的细胞介导的免疫应答和抗体应答,包含带有此种抗原的巨噬细胞和T、B细胞之间的一系列复杂的相互作用。这些细胞间的相互作用及其信息传递是由若干可溶性因子所介导。 T细胞产生的辅助因子对产生细胞毒的T淋巴细胞(CTL)的诱导,以及激发B细胞分化为抗体形成细胞之间的功能关系,进行了分析。用PPD刺激经结核杆菌(Tbc)致敏的T细胞培养物的无细胞上清液(CFS),即含有作用于CTL前体的杀伤辅助因子和使B细胞激活 The cell-mediated immune response and antibody response produced by antigen-stimulated organisms include a complex series of interactions between macrophages and T, B cells bearing such antigens. These cell-cell interactions and their transmission of information are mediated by several soluble factors. The cofactors produced by T cells were analyzed for the induction of cytotoxic T lymphocytes (CTLs) and for the functional relationship that stimulates B cells to differentiate into antibody-forming cells. Cell-free supernatant (CFS) of T cell cultures sensitized with Mycobacterium tuberculosis (Tbc) is stimulated with PPD, that is, with a cofactor that acts on CTL precursors and activates B cells