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60年代以来,开始对那些无法手术治疗的肝癌采取肝动脉插管栓塞(THAE)和肝动脉内化疗药物灌注等方法治疗,显示有一定的效果。但是,由于栓塞剂的早期吸收、血管再通或侧循枝环迅速形成。使肿瘤重新获得血供,从而影响栓塞的抗癌效果;另外,动脉血流的快速冲刷作用和酶降解作用使肿瘤组织内药物浓度下降,化疗作用迅速消失,同时大量药物进入周围循环,产生严重的全身毒性反应。近年来,国外许多学者开始采取经选择性肝动脉插管的方法,将由不同物质制成的带药微囊(Microcapsules)
Since the 1960s, hepatic arterial intubation embolization (THAE) and intrahepatic arterial infusion of chemotherapeutic drugs have begun to treat those liver cancers that cannot be surgically treated. This has shown certain effects. However, due to the early absorption of the embolic agent, recanalization of the blood vessel, or lateral rotation of the branch ring is rapidly formed. Regain blood supply to the tumor, thereby affecting the anti-cancer effect of embolization; In addition, the rapid flushing and enzymatic degradation of arterial blood flow reduce the concentration of drugs in the tumor tissue, the rapid disappearance of chemotherapy, and a large number of drugs into the surrounding circulation, resulting in serious Systemic toxicity. In recent years, many foreign scholars have begun adopting selective hepatic arterial catheterization methods. Microcapsules made of different substances