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目的:制备大红口服液,并制订其质量标准。方法:用正交试验对大红口服液的加水量、煎煮时间、醇沉次数进行优选。采用薄层扫描法定性鉴别,采用高效液相色谱法进行定量分析。结果:以8倍生药质量的水、每次煎煮30 min、醇沉1次(85%)的工艺提取效果最佳,薄层定性鉴别能从样品中检出相应的斑点。含量测定芦荟大黄素在0.031 9～0.111 7μg范围内有良好的线性关系,回收率为98.36%.RSD为2.2%。结论:该制剂制备工艺稳定,质量标准的定性定量方法灵敏、具有实用性。
Objective: To prepare Dahong oral liquid and formulate its quality standard. Methods: Orthogonal experiment was used to optimize the dosage of water, boiling time and alcohol precipitation of Dahong oral liquid. Thin-layer scans were used for statutory identification and high-performance liquid chromatography was used for quantitative analysis. RESULTS: The extraction effect was best with 8 times the raw material quality of water, 30 minutes of decocting, and 1 (85%) alcohol precipitation. The thin layer qualitative identification could detect the corresponding spots from the sample. The content of aloe-emodin in the assay ranged from 0.0319 to 0.111 7 μg. The recovery rate was 98.36%. RSD was 2.2%. Conclusion: The preparation process of this preparation is stable. The qualitative and quantitative methods of quality standards are sensitive and practical.