癌的骨转移是癌痛最常见的原因。本文探讨两种类型癌痛 ,即骨癌疼痛和癌症治疗导致疼痛的机制。Schwei等将肉瘤细胞植入小鼠的股骨 ,产生进行性骨质破坏 ,并伴随只有大剂量吗啡才能控制的自发和诱发性疼痛行为。在此模型中 ,患癌肢体接受非伤害刺激后 ,P物质受体激活 ,脊神经中 Cancer bone metastases are the most common cause of cancer pain. This article examines two types of cancer pain, namely, bone cancer pain and the mechanisms that lead to cancer treatment. Schwei et al. implanted sarcoma cells in the femur of mice, resulting in progressive bone destruction with spontaneous and induced pain behaviors that can only be controlled with large doses of morphine. In this model, after the cancerous limb receives non-nociceptive stimulation, the substance P receptor activates in the spinal nerves.