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目的：评价谷胱甘肽对化疗药物致肝损害的防治效果。方法：对１０２例化疗病人资料进行回顾性分析。治疗组１７例，男性９例，女性８例，年龄３７±ｓ１８ａ。肝功能异常开始用谷胱甘肽０．６～１．２ｇ，加１０％葡萄糖注射液２５０～５００ｍＬ，ｉｖ，ｇｔ，ｑｄ×１０～１４ｄ；预防组４６例（男性２８例，女性１８例；年龄３９±１３ａ），化疗前２ｄ至结束后１ｗｋ用谷胱甘肽（剂量、方法同上）；对照组３９例（男性２４例，女性１５例；年龄３８±１１ａ）只化疗，不用谷胱甘肽。结果：对照组肝损害发生率为４４％（１７／３９），预防组为１１％（５／４６）（Ｐ＜０．０１）。治疗组治疗后ＡＬＴ为３８±１６ＩＵ／Ｌ较治疗前（肝损害１２４±８３ＩＵ／Ｌ）差别有非常显著意义，Ｐ＜０．０１。结论：谷胱甘肽对化疗药物致肝损害有较好预防作用及治疗效果
Objective: To evaluate the effect of glutathione on liver damage caused by chemotherapeutic drugs. Methods: Retrospective analysis was performed on 102 patients with chemotherapy. The treatment group consisted of 17 patients, 9 males and 8 females, aged 37±s18a. Abnormal liver function began with glutathione 0.6 ~ 1.2g, plus 10% glucose injection 250 ~ 500mL, iv, gt, qd × 10 ~ 14d; preventive group of 46 cases (28 males and 18 females; Age 39±13a), Glutathione (dose, method Ibid.) 1dk before chemotherapy, and 39 cases (male 24, female 15; age 38±11a) chemotherapy only, without GSH Peptide. Results: The incidence of hepatic damage was 44% (17/39) in the control group and 11% (5/46) in the prevention group (P<0.01). After treatment, the ALT level of 38±16 IU/L in the treatment group was significantly higher than that before treatment (124±83 IU/L in liver damage), P<0.01. Conclusion: Glutathione has better preventive effect and therapeutic effect on liver damage caused by chemotherapeutic drugs