论文部分内容阅读
目的 探讨哮喘患儿血清可溶性细胞间粘附分子 - 1(s ICAM- 1)、肿瘤坏死因子 - α(TNF- α)与最大呼气流速(PEF)的关系、临床意义及激素治疗对它们的影响。方法 分离哮喘发作期、缓解期患儿和健康对照组儿童血清 ,用双抗体夹心酶联免疫吸附试验 (EL ISA)法测定血清 s ICAM- 1、TNF- α水平 ,用微型峰流速仪测 PEF,并对其中 12例应用激素治疗前后各指标作比较。结果 1发作期哮喘患儿血清 s ICAM- 1、TNF- α分别显著高于缓解期和对照组 (P<0 .0 1或 <0 .0 5 ) ,PEF值发作期显著低于缓解期和对照组。 2哮喘发作期患儿血清 TNF- α与 s ICAM- 1水平成正相关 ;PEF值分别与 s ICAM- 1和TNF- α水平呈负相关。 3患儿血清 s ICAM- 1和 TNF- α激素治疗前分别高于治疗后 ,PEF则相反。结论 1ICAM- 1和 TNF-α在哮喘气道炎症形成中起重要作用 ,与 PEF均可作为临床监测哮喘病情的指标。2激素能有效地抑制 ICAM- 1和 TNF- α的表述 ,从而起到抗炎、防治哮喘的作用。
Objective To investigate the relationship between serum soluble intercellular adhesion molecule - 1 (s ICAM - 1), tumor necrosis factor - α (TNF - α) and maximal expiratory flow rate (PEF) in children with asthma and its clinical significance and the effects of hormone therapy on them influences. Methods Serum levels of sICAM-1 and TNF-α in children with asthma attack and in remission children and healthy control children were measured by ELISA method. PEF , And 12 of them were compared before and after the application of hormone therapy. Results Serum levels of s ICAM-1 and TNF-α in children with asthma at the first episode were significantly higher than those in the control group and the remission stage (P <0.01 or <0.05), respectively. The duration of PEF attack was significantly lower than that in the remission stage and Control group. Serum levels of TNF-α and s ICAM-1 in children with asthma attack were positively correlated. PEF values were negatively correlated with the levels of s ICAM-1 and TNF-α. 3 children with serum s ICAM-1 and TNF-α hormone before treatment were higher than after treatment, PEF is the opposite. Conclusions 1ICAM-1 and TNF-α play an important role in the formation of airway inflammation in asthma, and both PEF and PEF can be used as clinical indicators to monitor the condition of asthma. 2 hormone can effectively inhibit the expression of ICAM-1 and TNF-α, which play a role in anti-inflammatory, anti-asthma.