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Calcium(Ca~(2+))and reactive oxygen species(ROS)constitute the most importantintracellular signaling molecules participating in the regulation and integration ofdiverse cellular functions.Here we briefly review cross-talk between the two promi-nent signaling systems that finely tune the homeostasis and integrate functional-ity of Ca~(2+)and ROS in different types of cells.Ca~(2+)modulates ROS homeostasisby regulating ROS generation and annihilation mechanisms in both the mitochon-dria and the cytosol.Reciprocal redox regulation of Ca~(2+)homeostasis occurs indifferent physiological and pathological processes,by modulating componentsof the Ca~(2+)signaling toolkit and altering characteristics of local and global Ca~(2+)signals.Functionally,interactions between Ca~(2+)and ROS signaling systems canbe both stimulatory and inhibitory,depending on the type of target proteins,theROS species,the dose,duration of exposure,and the cell contexts.Such extensiveand complex cross-talk might enhance signaling coordination and integration,whereas abnormalities in either system might propagate into the other system andundermine the stability of both systems.
Calcium (Ca ~ (2 +)) and reactive oxygen species (ROS) constitute the most important intracellular signaling molecules in the regulation and integration of diverse cellular functions. Here we briefly review cross-talk between the two promi-nent signaling systems that finely tune the homeostasis and integrate functional-ity of Ca ~ (2+) and ROS in different types of cells. Ca ~ (2+) modulates ROS homeostasis by regulating ROS generation and annihilation mechanisms in both the mitochon-dria and the cytosol. Reciprocal redox regulation of Ca ~ (2+) homeostasis occurs indifferent physiological and pathological processes, by modulating componentsof the Ca ~ (2+) signaling toolkit and altering characteristics of local and global Ca ~ (2+) signals. +) and ROS signaling systems canbe both stimulatory and inhibitory, depending on the type of target proteins, the ROS species, the dose, duration of exposure, and the cell contexts.Such extensive and complex cross-talk might enhance signaling coordination and integration, there abnormality in either system may propagate into the other system and undermine the stability of both systems.