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维生素D又称抗佝偻病维生素,是一种类固醇激素,主要来源于皮肤经紫外线照射后合成,少数来自于饮食摄取。维生素D只有经过羟化酶的催化才具有生物活性。维生素D首先在肝内25-羟化酶的作用下形成25羟维生素D3,然后又在肾近端小管1α-羟化酶的催化下成为活性更高的1,25-二羟维生素D3(1,25(OH)2D3)。维生素D类似物又称维生素D受体激动剂(VDRA),具有维生素D相似
Vitamin D, also known as anti-rickets vitamin, is a steroid hormone, mainly from the skin after ultraviolet radiation synthesis, a small number from diet intake. Vitamin D is bioactive only after hydroxylase catalysis. Vitamin D first forms 25 hydroxyvitamin D3 under the action of 25-hydroxylase in the liver and then becomes more active 1,25-dihydroxyvitamin D3 (1) catalyzed by the renal proximal tubule 1α-hydroxylase , 25 (OH) 2D3). Vitamin D analogues, also known as vitamin D receptor agonist (VDRA), with similar vitamin D