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急性白血病、恶性淋巴肿瘤、再生障碍性贫血等血液病,随着骨髓移植新疗法的应用,缓解率上升,但痊愈者仍不多见。为了提高疗效,对于抗感染及出血而采用的支持疗法已取得重大进展,尤其是现代抗生素的出现占有重要的位置。目前常见的血液病有并发感染症,患者免疫功能低下,正常中性白细胞减少等特异性症状(机会感染),其难治程度可想而知。致病菌以绿脓假单胞杆菌、克雷伯氏肺炎杆菌、埃希氏大肠杆菌等G~-杆菌发生率较高,且多为败血症,因此有必要早期治疗,疑为败血症者应按败血症治疗。对这些常见感染所采用的支持疗法,抗G~-杆菌具有强大成力的抗生素发挥了重要作用,我们曾报道了各种抗生素单独应用的有效性。现将第三代头孢菌素的羟羧氧乙酰胺菌素(LMOX)与氨基糖甙类的妥布霉素(TOB)合用结果报道如下:
Acute leukemia, malignant lymphoma, aplastic anemia and other blood diseases, with the application of new therapies for bone marrow transplantation, the remission rate increased, but the cure is still rare. In order to improve the curative effect, great progress has been made in the supportive therapy for anti-infection and bleeding, especially the emergence of modern antibiotics. At present, common blood diseases are complicated with infectious diseases, patients with immune dysfunction, normal neutropenia and other specific symptoms (opportunistic infections), the degree of refractory can be imagined. Pathogens to Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli G ~ - such as a higher incidence, and mostly sepsis, it is necessary for early treatment, suspected sepsis should be according to Sepsis treatment. Supportive therapies used in these common infections play an important role in the development of antibiotics that have strong potency against G ~ -bacteria, and we have reported the effectiveness of various antibiotics alone. Now third-generation cephalosporins oxycarboxamycin (LMOX) and aminoglycosides tobramycin (TOB) combined results are reported as follows: