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对30例甲亢、23例甲减患者治疗前后和20例正常对照者测定血清T_C、T_G、HDL-c、LDL-c和apoA_1、B_(100)、C_Ⅱ及C_Ⅲ浓度。结果,甲亢患者上述血脂及apo浓度均有不同程度下降。其中HDL-c和apo A_1下降程度较轻,LDL-c/HDL-c和apo B_(100)/A_1比值明显下降;甲减患者相反,Tc/HDL-c和Tc/apoA_1比值明显升高,为冠心病发生率在甲亢时降低和甲减时升高找到了恰当的解释。同时发现,甲减患者血清TG比Tc-升高更明显,血清aim C_Ⅱ/C_Ⅲ比值下降可能是引起甲减患者血清TG升高的一个重要原因;血清甲状腺激素在多方面参与脂代谢的调节;恢复甲状腺功能的治疗是纠正其脂代谢紊乱的关键。
Serum levels of T_C, T_G, HDL-c, LDL-c and apoA_1, B_ (100), C_Ⅱ and C_III were measured before and after treatment of 30 hyperthyroidism patients and 23 hypothyroidism patients and 20 normal controls. Results, hyperthyroidism in patients with above-mentioned blood lipid and apo concentrations have decreased to varying degrees. HDL-c and apo A_1 were decreased to a lesser extent, the ratio of LDL-c / HDL-c and apo B_ (100) / A_1 was significantly decreased. On the contrary, the ratios of Tc / HDL- For the incidence of coronary heart disease in hyperthyroidism and hypothyroidism increased hypothyroidism to find the right explanation. Also found that hypothyroidism serum TG increased more significantly than Tc-, serum level of C Ⅱ / C_Ⅲ ratio may be the cause of hypothyroidism in patients with elevated serum TG is an important reason; serum thyroid hormone in many ways involved in lipid metabolism regulation; The treatment of thyroid function is the key to correct the disorder of lipid metabolism.