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本文用自己建立的放射免疫分析方法测定了12例肾上腺皮质机能亢进患者的血清骨钙素(BGP)含量。治疗前,肾上腺皮质机能亢进患者平均血清 BGP(?)±2SE 为2.5±0.5ng/ml,显著低于正常值(4.8±1.3ng/ml,P<0.01)。8例患者于手术治疗后2周复查,血清 BGP 恢复至正常水平(5.1±1.8ng/ml),本文结果提示,骨钙素测定是皮质类固醇抑制成骨细胞活性的一个敏感指标。
In this paper, using our own established radioimmunoassay method for the determination of serum BGP in 12 patients with adrenocortical hyperfunction. Before treatment, mean serum BGP (±) 2SE in patients with adrenocortical hyperfunction was 2.5 ± 0.5 ng / ml, which was significantly lower than the normal value (4.8 ± 1.3 ng / ml, P <0.01). Eight patients were reviewed 2 weeks after surgery and serum BGP returned to normal levels (5.1 ± 1.8 ng / ml). Our results suggest that osteocalcin is a sensitive marker of corticosteroid-induced osteoblast activity.