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目的:检测癌相关抗原125(A125)在胃癌腹膜转移病人血清中的表达状况并探讨其在胃癌腹膜转移中的诊断意义。方法:选择经病理证实的70例胃癌患者为研究对象,其中胃癌腹膜转移者和无腹膜转移者各35例,手术前一周用放射免疫法检测其血清中CA125含量,同时测定肿瘤相关抗原CA19-9和CEA作参照,术前常规行腹部B超或CT检查。剖腹探查时观察腹膜转移的部位、范围、数目及大小等。健康对照30例。结果:胃癌组血清CA125水平明显高于对照组(P<0.05)。在35例出现腹膜转移的胃癌患者中,血清CA125水平超过正常值(35U/ml)者有28例(80%),范围从87U/ml～480U/ml,其数值与腹膜转移的程度成正比;而无腹膜转移组的35例患者,只有1例血清CA125水平略有升高(47U/ml),两组间存在显著差异(P<0.01)。结论:血清CA125水平可作为胃癌腹膜转移有效的预测指标,CA125水平在出现腹膜转移的胃癌患者血清中显著升高,并提示预后不良。
Objective: To detect the expression of cancer-associated antigen 125 (A125) in the serum of patients with peritoneal metastasis of gastric cancer and to explore its diagnostic significance in peritoneal metastasis of gastric cancer. Methods: Seventy patients with pathologically confirmed gastric cancer were selected as study subjects, including 35 patients with peritoneal metastasis and 35 patients without peritoneal metastasis. One week before surgery, CA125 levels in serum were detected by radioimmunoassay. The levels of CA19- 9 and CEA for reference, routine preoperative abdominal B ultrasound or CT examination. Laparoscopic exploration of peritoneal metastasis to observe the location, scope, number and size. Healthy control in 30 cases. Results: The level of serum CA125 in gastric cancer group was significantly higher than that in control group (P <0.05). Among 35 gastric cancer patients with peritoneal metastasis, 28 (80%) had serum CA125 level above normal (35U / ml), ranging from 87U / ml to 480U / ml, the value of which was proportional to the degree of peritoneal metastasis In 35 cases without peritoneal metastasis group, only 1 case had a slight increase of serum CA125 level (47U / ml), there was a significant difference between the two groups (P <0.01). Conclusion: The level of serum CA125 can be used as an effective predictor of peritoneal metastasis of gastric cancer. The level of CA125 is significantly elevated in the serum of patients with peritoneal metastasis and suggests that the prognosis is poor.