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采用免疫组化法测定69例膀胱移行细胞癌中P53蛋白及增殖细胞核抗原（PCNA），结果表明，膀胱癌中P53蛋白的过度表达与病理分级无关，而与临床分期及预后有关．随着肿瘤分级、分期的增高．PCNA－LI呈明显上升趋势．P53蛋白过度表达或PCNA高表达组术后5年生存率明显低于P53蛋白非过度表达或PCNA低表达组．说明：P53蛋白的过度表达在膀胱癌发生、发展中起着一定作用，PCNA是判定膀胱癌恶性程度及预后的重要指标．膀胱癌中P53蛋白的过度表达与PCNA－LI相关．
Immunohistochemistry was used to detect the expression of P53 protein and proliferating cell nuclear antigen (PCNA) in 69 cases of transitional cell carcinoma of the bladder. The results showed that overexpression of P53 in bladder cancer was not associated with pathological grade, but was related to clinical stage and prognosis. With tumor grade, staging increased. PCNA-LI showed a clear upward trend. The 5-year survival rate of P53 overexpression or PCNA overexpression group was significantly lower than that of P53 overexpression or PCNA overexpression group. P53 protein overexpression plays an important role in the occurrence and development of bladder cancer. PCNA is an important index to determine the malignancy and prognosis of bladder cancer. Overexpression of P53 protein in bladder cancer is associated with PCNA-LI.