患者男,50岁。1983年6月初出现面色苍黄,晨尿呈浓茶色,伴有头昏、耳鸣、心悸、乏力及食欲减退等症状,于同年7月13日首次入院。当时检查皮肤及巩膜黄染,睑结膜苍白,肝脾及浅表淋巴结不肿大。Hb 4g％,RBC 91万/mm~3,WBC 5650/mm~3,P_t14.2万/mm~3,网织红细胞14％。尿胆红质、血抗人球蛋白试验阴性,尿胆原、尿隐血试验、尿含铁血黄素、血清胆红质定性试验间接反应、酸溶血试验均为 Male patient, 50 years old. Early June 1983 pale yellow, morning urine was dark brown, accompanied by dizziness, tinnitus, palpitations, fatigue and loss of appetite and other symptoms, the first hospitalized on July 13 the same year. At that time, check the skin and sclera yellow dye, pale conjunctiva, liver and spleen and superficial lymph nodes is not enlarged. Hb 4g%, RBC 910 000 / mm ~ 3, WBC 5650 / mm ~ 3, P_t 142 000 / mm ~ 3, reticulocyte 14%. Urinary bilirubin, blood anti-human globulin test negative, urinary gallbladder, urine occult blood test, urine hemosiderin, serum bilirubin qualitative test indirect reaction, acid hemolysis test were