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目的：探讨系统性红斑狼疮（SLE）孕妇外周血中的T淋巴细胞亚群的改变。方注：采用流式细胞仪对14例系统性红斑狼疮患者妊娠后（SLE＋NP组）的外周血T淋巴细胞亚群进行检测，并以18例系统性红斑狼疮非妊娠妇女（SLE组），2Z例正常非妊娠妇女（NNP组）作对照。结果：SLE＋NP组的CD3+、CD8+百分率与SLE，NNP组比较元显著性差异，而CD4+的百分率和CD4+／CD8+的比值都明显低于SLE和NNP组（P＜0．01）。结论：妊娠引起部分SLE病情复燃，可能与T细胞亚群的变化有关，CD4+／CD8+比值不失为临床监察SLE患者妊娠后疾病变化的一种有效手段。
Objective: To investigate the changes of T lymphocyte subsets in peripheral blood of pregnant women with systemic lupus erythematosus (SLE). Side Note: T lymphocyte subsets in peripheral blood of 14 patients with systemic lupus erythematosus after pregnancy (SLE + NP group) were detected by flow cytometry, and 18 cases of systemic lupus erythematosus non-pregnant women (SLE group), 2Z Cases of normal non-pregnant women (NNP group) as a control. Results: The percentage of CD3 + and CD8 + in SLE + NP group was significantly lower than that in SLE and NNP group, while the percentage of CD4 + / CD4 + / CD8 + group was significantly lower than that in SLE and NNP group (P <0.01). CONCLUSION: Pregnancy-induced partial reactivation of SLE may be related to the changes of T cell subsets. The ratio of CD4 + / CD8 + is an effective measure to monitor the change of disease after pregnancy in SLE patients.