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探讨川芎嗪对免疫再生障碍性贫血（再障）小鼠骨髓细胞ＣＤ_（３４）抗原分子表达的影响。方法：建立免疫介导的再障小鼠模型， ６．０Ｇｙ～~（６０）Ｃｏγ－射线照射和尾静脉输注淋巴细胞造成小鼠再障。分为正常组、再障组（对照组）、川芎嗪组，除正常组外均胃饲川芎嗪注射液 ４ｍｇ／次，１天 ２次，第 １０天用流式细胞仪检测各组小鼠骨髓细胞膜上 ＣＤ_（３４）抗原表达量。结果：川芎嗪 ＣＤ_（３４）抗原表达量的荧光强度（７７．６±６．５）明显高于再障组（６８．６±４．５，Ｐ＜０．０５），与正常组（８０．０±２．６）比较无明显差异。结论：川芎嗪通过影响骨髓微环境促进免疫再障小鼠的造血干、祖细胞增生，增加ＣＤ_（３４）抗原分子的表达。
To investigate the effect of ligustrazine on the expression of CD34 antigen in bone marrow cells of mice with immune aplastic anemia (AAF). Methods: Aplastic anemia mice model was established. 6.0Gy ~ (60) Coγ-ray irradiation and tail vein infusion of lymphocytes caused aplastic anemia in mice. Were divided into normal group, aplastic anemia group (control group), ligustrazine group, except the normal group were given ligustrazine injection 4mg / time, 1 day 2 times, the 10th day by flow cytometry in each group of mice The expression of CD34 antigen in bone marrow cell membrane. Results: The fluorescence intensity of ligustrazine CD_ (34) antigen expression (77.6 ± 6.5) was significantly higher than that of aplastic anemia group (68.6 ± 4.5, P <0.05) .0 ± 2.6) no significant difference compared. CONCLUSION: Tetramethylpyrazine can promote the proliferation of hematopoietic stem and progenitor cells and increase the expression of CD34 antigen in mice with immune-aplastic failure by affecting the bone marrow microenvironment.